Search a real antigen, codon-optimize it for the animal you're targeting, then assemble the mRNA construct, fold it, simulate the manufacturing run and price out the order. It all happens in one window on your own machine, with 350+ tools underneath when you need them.
Free while in development · macOS & Windows · your sequences stay on your computer
No stitching together five web tools and a spreadsheet. The design, the analysis and the numbers stay in one place, computed on your machine with BioPython, ViennaRNA and real codon-usage tables.
Re-code a protein for any host, including elephants, okapi and other conservation species. Real tables where they exist, clade-proxy where they don't, with a live before/after readout.
Assemble T7 promoter, 5′UTR, Kozak, signal peptide, antigen ORF, 3′UTR and poly(A) into a therapeutic-style mRNA, with every part's provenance cited.
Fold with the ViennaRNA engine for secondary structure, minimum free energy, and dsRNA/hairpin immunogenicity risk. Computed locally.
Walk the construct through an in-vitro-transcription run, get a graded manufacturability report, then estimate yield, kinetics, and an itemized order form.
Restriction mapping, Gibson and Golden Gate assembly, and primer design via primer3, with a built-in fallback for platforms where primer3 has no prebuilt wheel.
Virtual agarose gels, in-silico PCR, peptide property calculators, and pairwise or multiple alignment. The everyday bench assays, simulated.
Codon choice has to match the animal being dosed. Nucleora ships real codon tables built from NCBI RefSeq coding sequences for African elephant, Asian elephant and cattle. Where a species like okapi or bongo has almost no sequenced genes, it optimizes against a documented clade-anchored proxy and tells you that is what it did, rather than pretending the data exists.
A real walkthrough of the Nucleora interface, with genuine ViennaRNA folding, codon optimization and manufacturability scoring. No mockups.
Watch the demo